Dong, X. Charlie2017-06-082017-06-082015-08Dong, X. C. (2015). The Potential of Sestrins as Therapeutic Targets for Diabetes. Expert Opinion on Therapeutic Targets, 19(8), 1011–1015. http://doi.org/10.1517/14728222.2015.1044976https://hdl.handle.net/1805/12911Sestrins (Sesn1/2/3) belong to a small protein family that has versatile biological functions. In addition to initially characterized oxidoreductase activity, sestrins also have oxidoreductase-independent functions, including activation of AMP-activated protein kinase, inhibition of the mechanistic target of rapamycin complex 1 (mTORC1) and activation of mTORC2. As these kinases are important for metabolic regulation, sestrins have a favorable profile as potential therapeutic targets for metabolic diseases such as diabetes. Recent data are in line with such a notion. In this editorial, I have attempted to provide a brief update on the major findings in regard to sestrins in metabolism.en-USPublisher PolicyAttribution-NonCommercial-NoDerivs 3.0 United StatesMechanistic target of rapamycin complex 1Mechanistic target of rapamycin complex 2SestrinV-akt murine thymoma viral oncogene homologArticle