Eldanasory, Omar AbdelhayEljaaly, KhalidMemish, Ziad A.Al-Tawfiq, Jaffar A.2020-09-092020-09-092020-09-03Eldanasory, O. A., Eljaaly, K., Memish, Z. A., & Al-Tawfiq, J. A. (2020). Histamine release theory and roles of antihistamine in the treatment of cytokines storm of COVID-19. Travel Medicine and Infectious Disease. https://doi.org/10.1016/j.tmaid.2020.1018741477-8939https://hdl.handle.net/1805/23790Histamine initiates abnormal immune response leading to cytokine storm and multi-organs failure. Thus, the use of antihistaminic medications could result in a significant immune modulation which may help in the treatment of cytokine storm of COVID-19. Future studies could compare H2R antagonists with those of steroid therapy in addition to the effect of combination therapy in relation to standard therapy.en-USIUPUI Open Access PolicyCOVID-19HistamineCytokines StormAntihistaminesTreatmentArticle