Travers, Jeffrey B.Kemp, Michael G.Weir, Nathan M.Cates, ElizabethAlkawar, Abdulrahman M.Mahajan, Avinash S.Spandau, Dan F.2022-05-102022-05-102020-01Travers JB, Kemp MG, Weir NM, et al. Wounding with a microneedling device corrects the inappropriate ultraviolet B radiation response in geriatric skin. Arch Dermatol Res. 2020;312(1):1-4. doi:10.1007/s00403-019-02001-zhttps://hdl.handle.net/1805/28916Non-melanoma skin cancer primarily affects geriatric patients as evidenced by the fact that only 20% of these cancers are diagnosed in patients under the age of 60 years. Of importance, geriatric skin responds to procarcinogenic ultraviolet B radiation (UVB) in a manner that permits the establishment of tumor cells. Recent studies have indicated that wounding of geriatric skin with fractionated resurfacing lasers and dermabrasion upregulates fibroblast production of insulin-like growth factor-1 (IGF-1) and normalizes the procarcinogenic acute UVB response consisting of basal keratinocytes proliferating while still harboring unrepaired DNA damage. The present studies tested the ability of wounding with a commercially available microneedling device to upregulate IGF-1 levels and normalize the geriatric UVB response. Geriatric volunteers were treated with a microneedling device on buttock skin and 3 months later the IGF-1 levels and UVB responses tested in wounded vs control skin. Wounding via microneedling upregulated IGF-1 and resulted in lower levels of basal keratinocytes proliferating with unrepaired DNA damage. The ability of microneedling to protect against the formation of UVB-damaged proliferating keratinocytes indicates the potential of this wounding modality to reduce aging-associated non-melanoma skin cancer.en-USPublisher PolicyInsulin-like growth factor-1Ultraviolet B radiationWoundingArticle