Kennedy, Richard E.Wadley, Virginia G.McClure, Leslie A.Letter, Abraham J.Unverzagt, Frederick W.Crowe, MichaelNyenhius, DavidKelley, Brendan J.Kana, BhumikaMarceaux, JaniceTamura, Manjula KurellaHoward, VirginiaHoward, George2016-03-032016-03-032014-09Kennedy, R. E., Wadley, V. G., McClure, L. A., Letter, A. J., Unverzagt, F. W., Crowe, M., … Howard, G. (2014). Performance of the NINDS-CSN 5-Minute Protocol in a National Population-Based Sample. Journal of the International Neuropsychological Society : JINS, 20(8), 856–867. http://doi.org/10.1017/S13556177140007331355-6177https://hdl.handle.net/1805/8665Background In 2006, the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network (NINDS-CSN) Vascular Cognitive Impairment Harmonization Standards recommended a 5-Minute Protocol as a brief screening instrument for vascular cognitive impairment (VCI). We report demographically adjusted norms for the 5-Minute Protocol and its relation to other measures of cognitive function and cerebrovascular risk factors. Methods Cross-sectional analysis of 7,199 stroke-free adults in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study on the NINDS-CSN 5-Minute Protocol score. Results Total scores on the 5-Minute Protocol were inversely correlated with age and positively correlated with years of education, and performance on the Six-Item Screener, Word List Learning, and Animal Fluency (all p-values<0.001). Higher cerebrovascular risk on the Framingham Stroke Risk Profile (FSRP) was associated with lower total 5-Minute Protocol scores (p<0.001). The 5-Minute Protocol also differentiated between participants with and without confirmed stroke and with and without stroke symptom histories (p<0.001). Conclusions The NINDS-CSN 5-Minute Protocol is a brief, easily administered screening measure that is sensitive to cerebrovascular risk and offers a valid method of screening for cognitive impairment in populations at risk for VCI.en-USPublisher Policyscreeningcerebrovascular disordersepidemiologymemorysemantic fluencydepressionArticle