Browsing by Author "Su, Ying"

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    Coupling Coordination Relationship between Urban Sprawl and Urbanization Quality in the West Taiwan Strait Urban Agglomeration, China: Observation and Analysis from DMSP/OLS Nighttime Light Imagery and Panel Data
    (MDPI, 2020-10) Lu, Chunyan; Li, Lin; Lei, Yifan; Ren, Chunying; Su, Ying; Huang, Yufei; Chen, Yu; Lei, Shaohua; Fu, Weiwei; Earth Sciences, School of Science
    Urban sprawl is the most prominent characteristic of urbanization, and increasingly affects local and regional sustainable development. The observation and analysis of urban sprawl dynamics and their relationship with urbanization quality are essential for framing integrative urban planning. In this study, the urban areas of the West Taiwan Strait Urban Agglomeration (WTSUA) were extracted using nighttime light imagery from 1992 to 2013. The spatio-temporal characteristics and pattern of urban sprawl were quantitatively analyzed by combining an urban expansion rate index and a standard deviation ellipse model. The urbanization quality was assessed using an entropy weight model, and its relationship with urban sprawl was calculated by a coupling coordination degree model. The results showed that the urban area in the WTSUA experienced a significant increase, i.e., 18,806.73 km2, during the period 1992–2013. The central cities grew by 11.08% and noncentral cities by 27.43%, with a general uneven city rank-size distribution. The urban sprawl showed a circular expansion pattern, accompanied by a gradual centroid migration of urban areas from the southeast coast to the central-western regions. The coupling coordination level between urban expansion and urbanization quality increased from serious incoordination in 1992 to basic coordination in 2013. Dual driving forces involving state-led policies and market-oriented land reform had a positive influence on the harmonious development of urban sprawl and urbanization quality of the WTSUA. This research offers an effective approach to monitor changes in urban sprawl and explore the coupling coordination relationship between urban sprawl and urbanization quality. The study provides important scientific references for the formulation of future policies and planning for sustainable development in urban agglomerations.
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    HOXB7 is an ERα cofactor in the activation of HER2 and multiple ER target genes leading to endocrine resistance
    (American Association for Cancer Research, 2015-09) Jin, Kideok; Park, Sunju; Teo, Wei Wen; Korangath, Preethi; Cho, Sean Soonweng; Yoshida, Takahiro; Győrffy, Balázs; Goswami, Chirayu Pankaj; Nakshatri, Harikrishna; Cruz, Leigh-Ann; Zhou, Weiqiang; Ji, Hongkai; Su, Ying; Ekram, Muhammad; Wu, Zhengsheng; Zhu, Tao; Polyak, Kornelia; Sukumar, Saraswati; Surgery, School of Medicine
    Why breast cancers become resistant to tamoxifen despite continued expression of the estrogen receptor alpha (ERα) and what factors are responsible for high HER2 expression in these tumors remains an enigma. HOXB7 ChIP analysis followed by validation showed that HOXB7 physically interacts with ERα, and that the HOXB7-ERα complex enhances transcription of many ERα target genes including HER2. Investigating strategies for controlling HOXB7, our studies revealed that MYC, stabilized via phosphorylation mediated by EGFR-HER2 signaling, inhibits transcription of miRNA-196a, a HOXB7 repressor. This leads to increased expression of HOXB7, ER-target genes and HER2. Repressing MYC using small molecule inhibitors reverses these events, and causes regression of breast cancer xenografts. The MYC-HOXB7-HER2 signaling pathway is eminently targetable in endocrine-resistant breast cancer.