Effects of Chronic Alcohol and Repeated Deprivations on Dopamine D1 and D2 Receptor Levels in the Extended Amygdala of Inbred Alcohol-Preferring Rats

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dc.contributor.authorSari, Youssef
dc.contributor.authorBell, Richard L.
dc.contributor.authorZhou, Feng C.
dc.contributor.departmentDepartment of Anatomy & Cell Biology, IU School of Medicineen_US
dc.date.accessioned2016-04-19T15:58:46Z
dc.date.available2016-04-19T15:58:46Z
dc.date.issued2006-01
dc.description.abstractBackground Dopaminergic (DA) activity in the extended amygdala (EA) has been known to play a pivotal role in mediating drug and alcohol addiction. Alterations of DA activity within the EA after chronic exposure to alcohol or substances of abuse are considered a major mechanism for the development of alcoholism and addiction. To date, it is not clear how different patterns of chronic alcohol drinking affect DA receptor levels. Therefore, the current studies investigated the effects of chronic ethanol consumption, with or without deprivations, on D1 and D2 receptor densities within the EA. Methods Inbred alcohol-preferring (iP) rats were divided into 3 groups with the following treatments: (1) water for 14 weeks; (2) continuous alcohol (C-Alc) for 14 weeks [24-hour concurrent access to 15 and 30% (v/v) ethanol]; or (3) repeatedly deprived of alcohol (RD-Alc) (24-hour concurrent access to 15 and 30% ethanol for 6 weeks, followed by 2 cycles of 2 weeks of deprivation of and 2 weeks of reexposure to ethanol access). At the end of 14 weeks, the rats were killed for autoradiographic labeling of D1 and D2 receptors. Results Compared with the water control group, both the C-Alc and the RD-Alc groups displayed increases in D1 receptor binding density in the anterior region of the Acb core, whereas the RD-Alc group displayed additional increases in D1 receptor binding density in anterior regions of the lateral and intercalated nuclei of the amygdala. Additionally, both C-Alc and RD-Alc rats displayed increases in D2 receptor binding density in anterior regions of the Acb shell and core, whereas RDAlc rats displayed additional increases in D2 receptor binding density in the dorsal striatum. Conclusion The results of this study indicate that 14-week extended alcohol drinking with continuous chronic or repeated deprivations increase binding sites of D1 and D2 receptors in specific regions of the EA with greater sensitivity in the anterior regions. The repeated deprivation has greater effect on altering D1 and D2 receptor binding sites in the Acb, dorsal striatum, and subamygdala regions. The current result indicates that the two drinking paradigms may have common as well as differential mechanisms on alteration of dopamine receptor–binding sites in specific regions of the EA.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationSari, Y., Bell, R. L., & Zhou, F. C. (2006). Effects of Chronic Alcohol and Repeated Deprivations on Dopamine D1 and D2 Receptor Levels in the Extended Amygdala of Inbred Alcohol-Preferring Rats. Alcoholism, Clinical and Experimental Research, 30(1), 46–56. http://doi.org/10.1111/j.1530-0277.2006.00010.xen_US
dc.identifier.issn0145-6008en_US
dc.identifier.urihttps://hdl.handle.net/1805/9321
dc.language.isoen_USen_US
dc.publisherWiley Blackwell (Blackwell Publishing)en_US
dc.relation.isversionof10.1111/j.1530-0277.2006.00010.xen_US
dc.relation.journalAlcoholism, clinical and experimental researchen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectAlcoholismen_US
dc.subjectpathologyen_US
dc.subjectAmygdalaen_US
dc.subjectReceptors, Dopamine D1en_US
dc.subjectanalysisen_US
dc.subjectReceptors, Dopamine D2en_US
dc.subjectSubstance Withdrawal Syndromeen_US
dc.titleEffects of Chronic Alcohol and Repeated Deprivations on Dopamine D1 and D2 Receptor Levels in the Extended Amygdala of Inbred Alcohol-Preferring Ratsen_US
dc.typeArticleen_US
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