The law of crime concentration at place has become a criminological axiom and the foundation for one of the strongest evidence-based policing strategies to date. Using longitudinal data from three sources, emergency medical service calls, death toxicology reports from the Marion County (Indiana) Coroner’s Office, and police crime data, we provide four unique contributions to this literature. First, this study provides the first spatial concentration estimation of opioid-related deaths. Second, our findings support the spatial concentration of opioid deaths and the feasibility of this approach for public health incidents often outside the purview of traditional policing. Third, we find that opioid overdose death hot spots spatially overlap with areas of concentrated violence. Finally, we apply a recent method, corrected Gini coefficient, to best specify low-N incident concentrations and propose a novel method for improving upon a shortcoming of this approach. Implications for research and interventions are discussed.