Cell-Cycle-Based Strategies to Drive Myocardial Repair

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dc.contributor.authorZhu, Wuqiang
dc.contributor.authorHassink, Rutger J.
dc.contributor.authorRubart, Michael
dc.contributor.authorField, Loren J.
dc.contributor.departmentPediatrics, School of Medicineen_US
dc.date.accessioned2020-12-16T16:17:31Z
dc.date.available2020-12-16T16:17:31Z
dc.date.issued2009-04-02
dc.description.abstractCardiomyocytes exhibit robust proliferative activity during development. After birth, cardiomyocyte proliferation is markedly reduced. Consequently, regenerative growth in the postnatal heart via cardiomyocyte proliferation (and, by inference, proliferation of stem-cell-derived cardiomyocytes) is limited and often insufficient to affect repair following injury. Here, we review studies wherein cardiomyocyte cell cycle proliferation was induced via targeted expression of cyclin D2 in postnatal hearts. Cyclin D2 expression resulted in a greater than 500-fold increase in cell cycle activity in transgenic mice as compared to their nontransgenic siblings. Induced cell cycle activity resulted in infarct regression and concomitant improvement in cardiac hemodynamics following coronary artery occlusion. These studies support the notion that cell-cycle-based strategies can be exploited to drive myocardial repair following injury.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationZhu, W., Hassink, R.J., Rubart, M. et al. Cell-Cycle-Based Strategies to Drive Myocardial Repair. Pediatr Cardiol 30, 710–715 (2009). https://doi.org/10.1007/s00246-009-9408-3en_US
dc.identifier.urihttps://hdl.handle.net/1805/24631
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s00246-009-9408-3en_US
dc.relation.journalRiley Symposiumen_US
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourcePublisheren_US
dc.subjectHeart regenerationen_US
dc.subjectCardiomyocyte proliferationen_US
dc.subjectCell cycleen_US
dc.titleCell-Cycle-Based Strategies to Drive Myocardial Repairen_US
dc.typeArticleen_US
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