Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease

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dc.contributor.authorKhambu, Bilon
dc.contributor.authorYan, Shengmin
dc.contributor.authorHuda, Nazmul
dc.contributor.authorLiu, Gang
dc.contributor.authorYin, Xiao-Ming
dc.contributor.departmentPathology and Laboratory Medicine, School of Medicineen_US
dc.date.accessioned2019-08-13T14:54:01Z
dc.date.available2019-08-13T14:54:01Z
dc.date.issued2018-09
dc.description.abstractAutophagy is an evolutionarily conserved intracellular degradative function that is important for liver homeostasis. Accumulating evidence suggests that autophagy is deregulated during the progression and development of alcoholic and non-alcoholic liver diseases. Impaired autophagy prevents the clearance of excessive lipid droplets (LDs), damaged mitochondria, and toxic protein aggregates, which can be generated during the progression of various liver diseases, thus contributing to the development of steatosis, injury, steatohepatitis, fibrosis, and tumors. In this review, we look at the status of hepatic autophagy during the pathogenesis of alcoholic and non-alcoholic liver diseases. We also examine the mechanisms of defects in autophagy, and the hepato-protective roles of autophagy in non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD), focusing mainly on steatosis and liver injury. Finally, we discuss the therapeutic potential of autophagy modulating agents for the treatment of these two common liver diseases.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationKhambu, B., Yan, S., Huda, N., Liu, G., & Yin, X. M. (2018). Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease. Liver research, 2(3), 112–119. doi:10.1016/j.livres.2018.09.004en_US
dc.identifier.urihttps://hdl.handle.net/1805/20339
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.livres.2018.09.004en_US
dc.relation.journalLiver Researchen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectAutophagyen_US
dc.subjectNon-alcoholic fatty liver disease (NAFLD)en_US
dc.subjectAlcoholic liver disease (ALD)en_US
dc.subjectLiver injuryen_US
dc.subjectSteatosisen_US
dc.titleAutophagy in non-alcoholic fatty liver disease and alcoholic liver diseaseen_US
dc.typeArticleen_US
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