Temporal Trends in Stroke Incidence over Time by Sex and Age in the Greater Cincinnati Northern Kentucky Stroke Study

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dc.contributor.authorMadsen, Tracy E.
dc.contributor.authorKhoury, Jane C.
dc.contributor.authorLeppert, Michelle
dc.contributor.authorAlwell, Kathleen
dc.contributor.authorMoomaw, Charles J.
dc.contributor.authorSucharew, Heidi
dc.contributor.authorWoo, Daniel
dc.contributor.authorFerioli, Simona
dc.contributor.authorMartini, Sharyl
dc.contributor.authorAdeoye, Opeolu
dc.contributor.authorKhatri, Pooja
dc.contributor.authorFlaherty, Matthew
dc.contributor.authorDe Los Rios La Rosa, Felipe
dc.contributor.authorMackey, Jason
dc.contributor.authorMistry, Eva
dc.contributor.authorDemel, Stacie L.
dc.contributor.authorColeman, Elisheva
dc.contributor.authorJasne, Adam
dc.contributor.authorSlavin, Sabreena J.
dc.contributor.authorWalsh, Kyle
dc.contributor.authorStar, Michael
dc.contributor.authorBroderick, Joseph P.
dc.contributor.authorKissela, Brett M.
dc.contributor.authorKleindorfer, Dawn O.
dc.contributor.departmentNeurology, School of Medicineen_US
dc.date.accessioned2022-08-24T12:12:18Z
dc.date.available2022-08-24T12:12:18Z
dc.date.issued2020-04
dc.description.abstractBackground and Purpose- Sex differences in stroke incidence over time were previously reported from the GCNKSS (Greater Cincinnati/Northern Kentucky Stroke Study). We aimed to determine whether these differences continued through 2015 and whether they were driven by particular age groups. Methods- Within the GCNKSS population of 1.3 million, incident (first ever) strokes among residents ≥20 years of age were ascertained at all local hospitals during 5 periods: July 1993 to June 1994 and calendar years 1999, 2005, 2010, and 2015. Out-of-hospital cases were sampled. Sex-specific incidence rates per 100 000 were adjusted for age and race and standardized to the 2010 US Census. Trends over time by sex were compared (overall and age stratified). Sex-specific case fatality rates were also reported. Bonferroni corrections were applied for multiple comparisons. Results- Over the 5 study periods, there were 9733 incident strokes (56.3% women). For women, there were 229 (95% CI, 215-242) per 100 000 incident strokes in 1993/1994 and 174 (95% CI, 163-185) in 2015 (P<0.05), compared with 282 (95% CI, 263-301) in 1993/1994 to 211 (95% CI, 198-225) in 2015 (P<0.05) in men. Incidence rates decreased between the first and last study periods in both sexes for IS but not for intracerebral hemorrhage or subarachnoid hemorrhage. Significant decreases in stroke incidence occurred between the first and last study periods for both sexes in the 65- to 84-year age group and men only in the ≥85-year age group; stroke incidence increased for men only in the 20- to 44-year age group. Conclusions- Overall stroke incidence decreased from the early 1990s to 2015 for both sexes. Future studies should continue close surveillance of sex differences in the 20- to 44-year and ≥85-year age groups, and future stroke prevention strategies should target strokes in the young- and middle-age groups, as well as intracerebral hemorrhage.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationMadsen TE, Khoury JC, Leppert M, et al. Temporal Trends in Stroke Incidence Over Time by Sex and Age in the GCNKSS [published correction appears in Stroke. 2020 Jul;51(7):e141]. Stroke. 2020;51(4):1070-1076. doi:10.1161/STROKEAHA.120.028910en_US
dc.identifier.urihttps://hdl.handle.net/1805/29857
dc.language.isoen_USen_US
dc.publisherAmerican Heart Associationen_US
dc.relation.isversionof10.1161/STROKEAHA.120.028910en_US
dc.relation.journalStrokeen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectStrokeen_US
dc.subjectStroke in young adultsen_US
dc.subjectSex-specificen_US
dc.subjectIschemic strokeen_US
dc.subjectCerebrovascular diseaseen_US
dc.titleTemporal Trends in Stroke Incidence over Time by Sex and Age in the Greater Cincinnati Northern Kentucky Stroke Studyen_US
dc.typeArticleen_US
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