Within academic research, individual philanthropy directed to women’s and girls’ causes has been understudied. This study highlights new data to understanding who gives to women’s and girls’ causes and their motivations for support. We conducted a two-part, mixed-methods study in the United States. First, we fielded a brief survey among a nationally representative survey panel. Second, we conducted seven focus groups among United Way and women’s fund donors who actively funded women’s and girls’ causes as well as donors who focused on other areas in their giving. In the survey, we find that among people giving to charity, half of women and 40 percent of men self-report giving to at least one cause that primarily affects women and girls. Women are both more likely to give to women’s and girls’ causes and give larger amounts to these causes, and are more likely to report giving to domestic violence organizations, women’s centers, LGBT rights, cancer care and research, and economic opportunities for women and girls. In the focus groups, women report giving to women’s and girls’ causes based on their personal experiences, including experiencing discrimination and having children, and because they believe giving to women and girls provides the best social return. Barriers to giving to women’s and girls’ causes include the complexity and scalability of women’s issues, the sex-segregated nature of women’s giving, and the connection to political issues which are often embedded in women’s causes. While this study provides valuable new research, more research is needed to understand generational differences among donors and how organizations focusing on women and girls can increase donor support.