Department of Oral Pathology, Medicine and Radiology Works
Permanent URI for this collection
Browse
Recent Submissions
Item Psychometric Characteristics of Oral Pathology Test Items in the Dental Hygiene Curriculum—A Longitudinal Analysis(MDPI, 2021-05-13) Srinivasan, Mythily; Oral Pathology, Medicine and Radiology, School of DentistryAs the landscape of oral healthcare and the delivery of services continue to undergo change, the dental hygienist plays an increasing role in assisting dentists with oral diagnosis and preventive strategies. Hence, the dental hygiene curriculum standards require biomedical science instructions, including general and oral pathology. Student learning and cognitive competencies are often measured using multiple-choice questions (MCQs). The objectives of this study were to perform a longitudinal analysis of test items and to evaluate their relation to the absolute grades of the oral pathology course in the dental hygiene curriculum. A total of 1033 MCQs covering different concepts of oral pathology administered from 2015 through 2019 were analyzed for difficulty and discriminatory indices, and the differences between the years were determined by one-way ANOVA. Test reliability as determined by the average KR-20 value was 0.7 or higher for each exam. The mean difficulty index for all exams was 0.73 +/− 0.05, and that of the discriminatory index was 0.33 +/− 0.05. Wide variations were observed in the discriminatory indices of test items with approximately the same difficulty index, as well as in the grade distribution in each cohort. Furthermore, longitudinal data analyses identified low achieving cohorts amongst the groups evaluated for the same knowledge domain, taught with the same instruction, and using similar test tools. This suggest that comparative analyses of tests could offer feedback not only on student learning attributes, but also potentially on the admission processes to the dental hygiene program.Item Taste Dysfunction and Long COVID-19(Frontiers, 2021-07-14) Srinivasan, Mythily; Oral Pathology, Medicine and Radiology, School of DentistrySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for the coronavirus disease 2019 (COVID-19), has imposed unprecedented morbidity and mortality worldwide. As of June 2021, globally over 163 million individuals are infected and nearly 3.4 million individuals have died. Emerging concerns include complaints of persistent symptoms for extended periods in recovered individuals. Cellular damage due to disease and/or treatment, prolonged viral shedding, chronic immune inflammatory response, and pro-coagulant state induced by SARS-CoV-2 infection are suggested mechanisms contributing to the symptom sequelae.Item CERE-120 Prevents Irradiation-Induced Hypofunction and Restores Immune Homeostasis in Porcine Salivary Glands(Elsevier, 2020-09-11) Lombaert, Isabelle M. A.; Patel, Vaishali N.; Jones, Christina E.; Villier, Derrick C.; Canada, Ashley E.; Moore, Matthew R.; Berenstein, Elsa; Zheng, Changyu; Goldsmith, Corinne M.; Chorini, John A.; Martin, Daniel; Zourelias, Lee; Trombetta, Mark G.; Edwards, Paul C.; Meyer, Kathleen; Ando, Dale; Passineau, Michael J.; Hoffman, Matthew P.; Oral Pathology, Medicine and Radiology, School of DentistrySalivary gland hypofunction causes significant morbidity and loss of quality of life for head and neck cancer patients treated with radiotherapy. Preventing hypofunction is an unmet therapeutic need. We used an adeno-associated virus serotype 2 (AAV2) vector expressing the human neurotrophic factor neurturin (CERE-120) to treat murine submandibular glands either pre- or post-irradiation (IR). Treatment with CERE-120 pre-IR, not post-IR, prevented hypofunction. RNA sequencing (RNA-seq) analysis showed reduced gene expression associated with fibrosis and the innate and humoral immune responses. We then used a minipig model with CERE-120 treatment pre-IR and also compared outcomes of the contralateral non-IR gland. Analysis of gene expression, morphology, and immunostaining showed reduced IR-related immune responses and improved secretory mechanisms. CERE-120 prevented IR-induced hypofunction and restored immune homeostasis, and there was a coordinated contralateral gland response to either damage or treatment. CERE-120 gene therapy is a potential treatment for head and neck cancer patients to influence communication among neuronal, immune, and epithelial cells to prevent IR-induced salivary hypofunction and restore immune homeostasis.Item TMD-SD (Symptom Descriptives)(2021-02-02) Avila, Harold; Kroenke, KurtForm used while interviewing a TMD patient to systematically record information related to pain symptoms experienced by a person having TMD pain symptoms.Item TMD-SI (Symptom Identification) Form(2021-02-02) Avila, Harold; Kroenke, KurtForm completed by a person having TMD Pain Symptoms for the purpose of identifying which pain symptoms the person is having which may also be caused by their TMDs.Item TMD-SST (Symptom Severity Tracker) Form(2020) Avila, Harold; Kroenke, KurtForm for monitoring the severity of symptoms experienced by patients having TMD.Item TMD-XI (Exam Interview) Form(2020) Avila, Harold; Kroenke, KurtA form to assist the healthcare provider in obtaining patient information on patients experiencing TMD symptoms.Item TMD-PX (Physical Exam)(2020) Avila, Harold; Kroenke, KurtForm for completing a Physical Exam of a patient experiencing TMD.Item TMD-7, Brief patient completed questionnaire(2020-02-22) Avila, Harold; Kroenke, KurtA brief survey used by a healthcare professional to quickly learn the degree of pain/loss of function a patient is experiencing from their possible Temporomandibular Joint Disorder.Item Enamel defects, cavities in primary dentition, fluoride sources and their relationship to cavitiesin permanent teeth defect Enamels, cavities in primary dentition and fluoride sources: relationship with caries in permanent teeth(Elsevier, 2007-05) Vallejos-Sánchez, Ana Alicia; Medina-Solís, Carlo Eduardo; Casanova-Rosado, Juan Fernando; Maupomé, Gerardo; Casanova-Rosado, Alejandro José; Minaya-Sánchez, Mirna; Oral Pathology, Medicine and Radiology, School of DentistryOBJECTIVE:To examine the relationship between the presence of enamel defects, dental caries in primary teeth, and exposure to various fluoride technologies and the presence of dental caries in permanent teeth in children with mixed dentition. MATERIALS AND METHODS:A cross-sectional study was conducted in 713 children aged 6-9 years old in 4 elementary schools in Campeche, Mexico through the use of a questionnaire for the mothers and an oral examination in the children. The dependent variable was the prevalence of caries in permanent dentition. RESULTS:The mean number of decay, missing or filling teeth in primary dentition (dmft) and in permanent dentition (DMFT) was 2.48 (2.82) (deft > 0 = 58.9%) and 0.40 (0.98) (DMFT > 0 = 18.2%), respectively. The significant caries index (SiC), which is calculated in deciduous dentition, was 5.85 for 6 year-olds. Multivariate logistic regression adjusted for variables related to fluoride exposure revealed that older age (OR = 2.99), a deft of > 0 (OR = 5.46), and lower maternal educational level (OR = 1.57) were significantly associated with a higher number of dental caries in permanent teeth. An interaction between sex and enamel defects was also found. CONCLUSIONS:The number of dental caries in both primary and permanent dentitions was relatively smaller than that found in prior studies performed in Mexican populations. The results confirm that the presence of caries in primary dentition is strongly associated with caries in permanent dentition. No significant relationship was found between fluoride exposure and dental caries in permanent dentition.