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Item THIS IS A TEST: Gas and stuff(IUPUI, 2023) Odell, JereItem 17β-Estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin(American Society for Clinical Investigation, 2021-03-15) Frump, Andrea L.; Albrecht, Marjorie; Yakubov, Bakhtiyor; Breuils-Bonnet, Sandra; Nadeau, Valérie; Tremblay, Eve; Potus, Francois; Omura, Junichi; Cook, Todd; Fisher, Amanda; Rodriguez, Brooke; Brown, R. Dale; Stenmark, Kurt R.; Rubinstein, C. Dustin; Krentz, Kathy; Tabima, Diana M.; Li, Rongbo; Sun, Xin; Chesler, Naomi C.; Provencher, Steeve; Bonnet, Sebastien; Lahm, Tim; Medicine, School of MedicineWomen with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV) function and survival than men; however, the underlying mechanisms are unknown. We hypothesized that 17β-estradiol (E2), through estrogen receptor α (ER-α), attenuates PAH-induced RV failure (RVF) by upregulating the procontractile and prosurvival peptide apelin via a BMPR2-dependent mechanism. We found that ER-α and apelin expression were decreased in RV homogenates from patients with RVF and from rats with maladaptive (but not adaptive) RV remodeling. RV cardiomyocyte apelin abundance increased in vivo or in vitro after treatment with E2 or ER-α agonist. Studies employing ER-α–null or ER-β–null mice, ER-α loss-of-function mutant rats, or siRNA demonstrated that ER-α is necessary for E2 to upregulate RV apelin. E2 and ER-α increased BMPR2 in pulmonary hypertension RVs and in isolated RV cardiomyocytes, associated with ER-α binding to the Bmpr2 promoter. BMPR2 is required for E2-mediated increases in apelin abundance, and both BMPR2 and apelin are necessary for E2 to exert RV-protective effects. E2 or ER-α agonist rescued monocrotaline pulmonary hypertension and restored RV apelin and BMPR2. We identified what we believe to be a novel cardioprotective E2/ER-α/BMPR2/apelin axis in the RV. Harnessing this axis may lead to novel RV-targeted therapies for PAH patients of either sex.Item Negotiate Like An MBA: A Virtual Workshop(2022-05-17) Macy, Katharine V.; Ameen, MahasinThe art of negotiation is an important skillset for information professionals who often lack formalized training. Participants in this workshop will learn a framework that enables effective negotiation preparation as well as develop and practice new skills and strategies around conducting principled negotiations with external partners. Over three sessions, participants will learn key concepts and strategies such as BATNA (Best Alternative to Negotiated Agreement) and ZOPA (Zone of Possible Agreement) which are useful in planning offers and counteroffers. Strategies around how to prepare when you have little time, hear the word no, and experience poor behavior mid-negotiation will be also discussed. Participants will be provided case studies to practice negotiation preparation, and will have the opportunity to execute three negotiations, one on negotiating a job offer and two based on negotiating electronic resources. In the two e-resource negotiations, everyone will have the chance to be either the library or the vendor. Participants should expect to do about an hour of homework before the second and third sessions to study the assigned case study and prepare to negotiate at the beginning of sessions 2 and 3.Item Investigating the Long-Term Outcomes of Service-Learning(2022-10) Schmalz, Naomi Alexandra; Byram, Jessica N.; Hoffman, Leslie A.; Organ, Jason M.; Palmer, Megan M.; Wisco, Jonathan J.Anatomy Academy (AA) is a service-learning program in which pre- and current health professional students (Mentors) work in pairs to teach anatomy, physiology, and nutrition to children in the community. The purpose of this study was to investigate the short- and long-term Mentor outcomes in personal, social, civic, academic, and professional domains. Former Mentors were invited to complete a survey of Likert-style and free response questions evaluating the perceived impact of their AA experience on: teaching skills, personal and interpersonal development, civic engagement, and academic and professional development. Follow-up interviews with a subset of survey respondents were performed. The survey was completed by 219 Mentors and 17 survey respondents were interviewed. Over 50% of former Mentors reported moderate or major impact of AA participation on elements of personal and interpersonal development (e.g., selfesteem [57.6%], altruism [67.9%], communication skills [60.1%], and ability to work with others [72.6%]) and community service participation (54.2%) that endures in the years after the program. Mentors who worked with low-income or Special needs populations reported unique impacts in personal, interpersonal, and civic domains. A majority of former Mentors agreed that AA participation helped them learn practical skills (76.3%) and factual knowledge (65.4%) relevant to the their careers, with several current health professionals reported that they regularly employ teaching and interpersonal skills learned while Mentors in their roles as physicians, nurses, or physician’s assistants. A majority of former Mentors reported that AA validated their choice to either pursue a healthcare career or not (59.7%), increased their confidence in performing professional tasks (64.7%), and helped shape their professional identity (58.9%). These results indicate that a health education-based service-learning program offers undergraduate, graduate, and professional students interested in or actively pursuing a healthcare career benefits across personal, interpersonal, civic, and professional domains that support their academic progress and preparation for professional practice. This study contributes much-needed evidence of the long-term student outcomes of service-learning to the literature, with a particular focus on how the pedagogy can supplement the education and professional development of pre- and current health professional students.Item Indiana University–Purdue University Indianapolis(University of South Carolina, 2017) Bowman, Heather; Powell, Amy; Buyarski, CathyItem Exploring Male And Female Healthcare Provider Communication With Alzheimer’s Patients: A Qualitative Study(2021-05) Lyu, Ying; Goering, Elizabeth; Head, Katharine J.; Bute, JenniferToday, Alzheimer’s is a devastating disease that affects more than 46.8 million people worldwide. Caring for people with AD is stressful and emotionally draining for both family members and healthcare providers and would be exacerbated by the breakdown in communication. While communication challenges can take many forms, one understudied area in AD patient-provider communication is how gender role might affect the outcomes and perceived feelings during interaction. Without knowledge and attentiveness of how gender may affect patient-provider communication, healthcare providers may become more frustrated in their attempts to apply unadjusted skills, which can cause further breakdown and stress. This study is to explore how gender might be a role affecting caregiving communication within the context of Alzheimer’s. Eleven participants were recruited to have a semi-structured interview through online flyers. The findings from this study yield broad suggestions for future work within the field of Alzheimer’s communication research and specific suggestions for designing the communication training.Item Catheter Removal on the Same Day of Holmium Laser Enucleation of the Prostate: Outcomes of a Pilot Study(Elsevier, 2020-10-09) Agarwal, Deepak K.; Rivera, Marcelino E.; Nottingham, Charles U.; Large, Tim; Krambeck, Amy E.; Department of Urology, IU School of MedicineObjectives: To determine if same day catheter removal is feasible in select population after holmium laser enucleation of the prostate (HoLEP). Methods: We performed an analysis of patients undergoing HoLEP at our institution who underwent same-day catheter removal after HoLEP. All HoLEPs were performed with Moses Optimized for BPH. Patients were dismissed from postoperative recovery unit (POCU) to the clinic for catheter removal and voiding trial. Results: To date, 30 patients have undergone same day catheter removal. Median age is 68.6 years (IQR 61.8-73.3) and preoperative prostate volume 81 ml (IQR 53-114.8). Median enucleation time was 39.5 min (IQR 30.5-53), morcellation time was 5 min (IQR 4-12 min) and enucleated specimen weight was 52.5 g (IQR 33-81). 27 (90%) patients successfully voided on the same day without requiring catheter replacement. All patients were catheter free by POD1. For patients who successfully passed their voiding trial, the median time from the end of the procedure to hospital discharge was 2.6 hours (IQR (2.1-2.9) and from the end of the HoLEP to catheter removal was 4.9 hours (IQR 3.5-6.0). Conclusions: We present for the first time that same day catheter removal is a feasible option in a select population of patients undergoing HoLEP. With more study, this has the potential for transforming the management of BPH, especially larger glands.Item Nonprofits and Donor-Advised Funds: Perceptions and Potential Impacts(2020-10-07) Osili, Una; Zarins, Sasha; Bergdoll, Jon; Buller, Melissa; Pruitt, AnnaDonor-advised funds (DAFs) foster a unique partnership among nonprofits, donors, and DAF sponsoring organizations to achieve philanthropic goals. DAFs are also one of the fastest growing charitable vehicles and most talked about topics in the field of philanthropy. It is essential to understand donors’ and nonprofit organizations’ perceptions of DAFs. Perceptions not only affect how and when DAFs are used, but they impact policymakers’ decisions about rules and regulations, thereby influencing the long-term efficacy of DAFs as a philanthropic vehicle.Item A Comparative Study of Microfinance/Women’s Empowerment Initiatives in Africa and Latin America(2018-04-10) Hook, Sara Anne; Lawler, AudraThis poster will compare and contrast microfinance/women’s empowerment initiatives in Kenya, Sierra Leone, Nicaragua and Mexico. It will provide a brief overview of each country included in the study and why it was chosen and compare various features of several of the microfinance organizations working in this country, including their level of sophistication, their processes and approaches, their collaboration with partners in the host countries, and the outcomes of their activities. The poster will also recommend ways that attendees can be involved with or support microfinance/women’s empowerment projects.Item Access to the Justices' Papers: A Better Balance(2018) deMaine, Susan DavidWith the exception of official court records, the papers generated by the Supreme Court justices in their work for the Court are and have always been considered private property. As a result, the justices’ treatment of these documents is idiosyncratic, ranging from outright destruction to lengthy restrictions to quick release. Adding the perspective of archivists and librarians, this paper explores the history of the justices’ papers and questions of access, the public’s interest in understanding the Court and its decisions, and the effect of the justices’ papers on scholarship and popular research. Several options for encouraging greater openness are proposed.