Open Access Publishing Fund

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The IUPUI Open Access Fund underwrites reasonable publication charges for articles published in fee-based, peer-reviewed journals that are openly accessible. This fund addresses changes in scholarly communications while increasing the impact of and access to scholarship created by IUPUI faculty. Learn more at: http://ulib.iupui.edu/digitalscholarship/openaccess/oafund

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Now showing 1 - 10 of 211

Clinical perspectives on hospitals’ role in the opioid epidemic
(BioMed Central, 2020-06-08) Mazurenko, Olena; Andraka-Christou, Barbara T.; Bair, Matthew J.; Kara, Areeba Y.; Harle, Christopher A.; Health Policy and Management, School of Public Health
Policymakers, legislators, and clinicians have raised concerns that hospital-based clinicians may be incentivized to inappropriately prescribe and administer opioids when addressing pain care needs of their patients, thus potentially contributing to the ongoing opioid epidemic in the United States. Given the need to involve all healthcare settings, including hospitals, in joint efforts to curb the opioid epidemic, it is essential to understand if clinicians perceive hospitals as contributors to the problem. Therefore, we examined clinical perspectives on the role of hospitals in the opioid epidemic.
Formation and evolution of an extensive blue ice moraine in central Transantarctic Mountains, Antarctica
(Cambridge UP, 2020-02) Kassab, Christine M.; Licht, Kathy J.; Petersson, Rickard; Lindbäck, Katrin; Graly, Joseph A.; Kaplan, Michael R.; Earth Sciences, School of Science
Mount Achernar moraine is a terrestrial sediment archive that preserves a record of ice-sheet dynamics and climate over multiple glacial cycles. Similar records exist in other blue ice moraines elsewhere on the continent, but an understanding of how these moraines form is limited. We propose a model to explain the formation of extensive, coherent blue ice moraine sequences based on the integration of ground-penetrating radar (GPR) data with ice velocity and surface exposure ages. GPR transects (100 and 25 MHz) both perpendicular and parallel to moraine ridges at Mount Achernar reveal an internal structure defined by alternating relatively clean ice and steeply dipping debris bands extending to depth, and where visible, to the underlying bedrock surface. Sediment is carried to the surface from depth along these debris bands, and sublimates out of the ice, accumulating over time (>300 ka). The internal pattern of dipping reflectors, combined with increasing surface exposure ages, suggest sequential exposure of the sediment where ice and debris accretes laterally to form the moraine. Subsurface structure varies across the moraine and can be linked to changes in basal entrainment conditions. We speculate that higher concentrations of debris may have been entrained in the ice during colder glacial periods or entrained more proximal to the moraine sequence.
Understanding Pregnant Women with Opioid Use Disorder
(Masters Program in Public Health, Universitas Sebelas Maret, 2019-11-19) Stiffler, Deborah; Amundson, Mia; Hapke, Lauren; Harvey, Emilie; Sizemore, Samantha; Smith, Savannah; School of Nursing
Background: Pregnant women with opioid use disorder are a major concern to the healthcare industry. They are not only one of the most stigmatized groups but are in need of outreach. Women who are afflicted by opioid addiction are a highly vulnerable group who are at risk of adverse pregnancy outcomes and perinatal complications. The purpose of this study was to do a meta-synthesis of the literature to gain a better understanding of the women’s perspective who are addicted to opioid during pregnancy. Subjects and Method: We conducted an exhaustive literature search for qualitative studies that focused on women with opioid used disorder during pregnancy and postpartum. After conducting a rigorous methodological protocol for meta-synthesis described by Joanna Briggs Institute, ten studies met the criteria for inclusion into this study. We used the Qualitative Assessment and Review Instrument (QARI) from the Joanna Briggs Institute to assist with data management. We extracted the representative quotations and categorized them into like themes. Results: There were three themes formulated from this meta-synthesis: overarching fear, trust, and educational deficits. This meta-synthesis of qualitative studies leads to a greater understanding of how pregnant women with opioid use disorder perceive the consequences of their actions. Conclusion: Implications from this meta-synthesis will inform those working with opioid-addicted pregnant women and aid in establishing best practices for them and their infants by revealing their addiction experiences and narratives.
Parity–Time Symmetry in Bidirectionally Coupled Semiconductor Lasers
(MDPI, 2019-12) Wilkey, Andrew; Suelzer, Joseph; Joglekar, Yogesh; Vemuri, Gautam; Physics, School of Science
We report on the numerical analysis of intensity dynamics of a pair of mutually coupled, single-mode semiconductor lasers that are operated in a configuration that leads to features reminiscent of parity–time symmetry. Starting from the rate equations for the intracavity electric fields of the two lasers and the rate equations for carrier inversions, we show how these equations reduce to a simple 2 × 2 effective Hamiltonian that is identical to that of a typical parity–time (PT)-symmetric dimer. After establishing that a pair of coupled semiconductor lasers could be PT-symmetric, we solve the full set of rate equations and show that despite complicating factors like gain saturation and nonlinearities, the rate equation model predicts intensity dynamics that are akin to those in a PT-symmetric system. The article describes some of the advantages of using semiconductor lasers to realize a PT-symmetric system and concludes with some possible directions for future work on this system.
Embryonic ethanol exposure alters expression of sox2 and other early transcripts in zebrafish, producing gastrulation defects
(Springer Nature, 2020-03-03) Sarmah, Swapnalee; Srivastava, Rajneesh; McClintick, Jeanette N.; Janga, Sarath C.; Edenberg, Howard J.; Marrs, James A.; Biology, School of Science
Ethanol exposure during prenatal development causes fetal alcohol spectrum disorder (FASD), the most frequent preventable birth defect and neurodevelopmental disability syndrome. The molecular targets of ethanol toxicity during development are poorly understood. Developmental stages surrounding gastrulation are very sensitive to ethanol exposure. To understand the effects of ethanol on early transcripts during embryogenesis, we treated zebrafish embryos with ethanol during pre-gastrulation period and examined the transcripts by Affymetrix GeneChip microarray before gastrulation. We identified 521 significantly dysregulated genes, including 61 transcription factors in ethanol-exposed embryos. Sox2, the key regulator of pluripotency and early development was significantly reduced. Functional annotation analysis showed enrichment in transcription regulation, embryonic axes patterning, and signaling pathways, including Wnt, Notch and retinoic acid. We identified all potential genomic targets of 25 dysregulated transcription factors and compared their interactions with the ethanol-dysregulated genes. This analysis predicted that Sox2 targeted a large number of ethanol-dysregulated genes. A gene regulatory network analysis showed that many of the dysregulated genes are targeted by multiple transcription factors. Injection of sox2 mRNA partially rescued ethanol-induced gene expression, epiboly and gastrulation defects. Additional studies of this ethanol dysregulated network may identify therapeutic targets that coordinately regulate early development.
A conjoint analysis study on self-sampling for human papillomavirus (HPV) testing characteristics among black women in Indiana
(BioMed Central, 2020-03-19) Biederman, Erika; Champion, Victoria; Zimet, Gregory; School of Nursing
Self-sampling for HPV testing may be a method to increase overall cervical cancer screening rates among Black women, who are underscreened for cervical cancer in parts of the US. The purpose of this study was to assess preferred characteristics for delivery of HPV self-sampling kits, return of HPV self-sampling kits, and communication of HPV test results and explore sociodemographic factors (income, education, and marital status) associated with acceptability of self-sampling for HPV testing.
Factors Related to User Ratings and User Downloads of Mobile Apps for Maternal and Infant Health: Cross-Sectional Study
(JMIR, 2020) Biviji, Rizwana; Vest, Joshua R.; Dixon, Brian E.; Cullen, Theresa; Harle, Christopher A.; Health Policy and Management, School of Public Health
Background: Mobile health apps related to maternal and infant health (MIH) are prevalent and frequently used. Some of these apps are extremely popular and have been downloaded over 5 million times. However, the understanding of user behavior and user adoption of these apps based on consumer preferences for different app features and categories is limited. Objective: This study aimed to examine the relationship between MIH app characteristics and users’ perceived satisfaction and intent to use. Methods: The associations between app characteristics, ratings, and downloads were assessed in a sample of MIH apps designed to provide health education or decision-making support to pregnant women or parents and caregivers of infants. Multivariable linear regression was used to assess the relationship between app characteristics and user ratings, and ordinal logistic regression was used to assess the relationship between app characteristics and user downloads. Results: The analyses of user ratings and downloads included 421 and 213 apps, respectively. The average user rating was 3.79 out of 5. Compared with the Apple App Store, the Google Play Store was associated with high user ratings (beta=.33; P =.005). Apps with higher standardized user ratings (beta=.80; P <.001), in-app purchases (beta=1.12; P =.002), and in-app advertisements (beta=.64; P =.02) were more frequently downloaded. Having a health care organization developer as part of the development team was neither associated with user ratings (beta=−.20; P =.06) nor downloads (beta=−.14; P =.63). Conclusions: A majority of MIH apps are developed by non–health care organizations, which could raise concern about the accuracy and trustworthiness of in-app information. These findings could benefit app developers in designing better apps and could help inform marketing and development strategies. Further work is needed to evaluate the clinical accuracy of information provided within the apps. [JMIR Mhealth Uhealth 2020;8(1):e15663]
A Virtual 3D Dynamic Model of Caries Lesion Progression as a Learning Object for Caries Detection Training and Teaching: Video Development Study
(JMIR, 2020-05-22) Lara, Juan Sebastian; Braga, Mariana Minatel; Zagatto, Carlos Gustavo; Wen, Chao Lung; Mendes, Fausto Medeiros; Murisi, Pedroza Uribe; Haddad, Ana Estela; Cariology, Operative Dentistry and Dental Public Health, School of Dentistry
BACKGROUND: In the last decade, 3D virtual models have been used for educational purposes in the health sciences, specifically for teaching human anatomy and pathology. These models provide an opportunity to didactically visualize key spatial relations that can be poorly understood when taught by traditional educational approaches. Caries lesion detection is a crucial process in dentistry that has been reported to be difficult to learn. One especially difficult aspect is linking clinical characteristics of the different severity stages with their histological features, which is fundamental for treatment decision-making. OBJECTIVE: This project was designed to develop a virtual 3D digital model of caries lesion formation and progression to aid the detection of lesions at different severity stages as a potential complement to traditional lectures. METHODS: Pedagogical planning, including identification of objectives, exploration of the degree of difficulty of caries diagnosis-associated topics perceived by dental students and lecturers, review of the literature regarding key concepts, and consultation of experts, was performed prior to constructing the model. An educational script strategy was created based on the topics to be addressed (dental tissues, biofilm stagnation areas, the demineralization process, caries lesion progression on occlusal surfaces, clinical characteristics related to different stages of caries progression, and histological correlations). Virtual 3D models were developed using the Virtual Man Project and refined using multiple 3D software applications. In the next phase, computer graphic modelling and previsualization were executed. After that, the video was revised and edited based on suggestions. Finally, explanatory subtitles were generated, the models were textured and rendered, and voiceovers in 3 languages were implemented. RESULTS: We developed a 6-minute virtual 3D dynamic video in 3 languages (English, Spanish, and Brazilian Portuguese) intended for dentists and dental students to support teaching and learning of caries lesion detection. The videos were made available on YouTube; to date, they have received more than 100,000 views. CONCLUSIONS: Complementary pedagogical tools are valuable to support cariology education. This tool will be further tested in terms of utility and usability as well as user satisfaction in achieving the proposed objectives in specific contexts.
Engagement and Usability of a Cognitive Behavioral Therapy Mobile App Compared With Web-Based Cognitive Behavioral Therapy Among College Students: Randomized Heuristic Trial
(JMIR, 2020) Purkayastha, Saptarshi; Addepally, Siva Abhishek; Bucher, Sherri; BioHealth Informatics, School of Informatics and Computing
Background: Recent evidence in mobile health has demonstrated that, in some cases, apps are an effective way to improve health care delivery. Health care interventions delivered via mobile technology have demonstrated both practicality and affordability. Lately, cognitive behavioral therapy (CBT) interventions delivered over the internet have also shown a meaningful impact on patients with anxiety and depression. Objective: Given the growing proliferation of smartphones and the trust in apps to support improved health behaviors and outcomes, we were interested in comparing a mobile app with Web-based methods for the delivery of CBT. This study aimed to compare the usability of a CBT mobile app called MoodTrainer with an evidence-based website called MoodGYM. Methods: We used convenience sampling to recruit 30 students from a large Midwestern university and randomly assigned them to either the MoodGYM or MoodTrainer user group. The trial period ran for 2 weeks, after which the students completed a self-assessment survey based on Nielsen heuristics. Statistical analysis was performed to compare the survey results from the 2 groups. We also compared the number of modules attempted or completed and the time spent on CBT strategies. Results: The results indicate that the MoodTrainer app received a higher usability score when compared with MoodGYM. Overall, 87% (13/15) of the participants felt that it was easy to navigate through the MoodTrainer app compared with 80% (12/15) of the MoodGYM participants. All MoodTrainer participants agreed that the app was easy to use and did not require any external assistance, whereas only 67% (10/15) had the same opinion for MoodGYM. Furthermore, 67% (10/15) of the MoodTrainer participants found that the navigation controls were easy to locate compared with 80% (12/15) of the MoodGYM participants. MoodTrainer users, on average, completed 2.5 modules compared with 1 module completed by MoodGYM users. Conclusions: As among the first studies to directly compare the usability of a mobile app–based CBT with smartphone-specific features against a Web-based CBT, there is an opportunity for app-based CBT as, at least in our limited trial, it was more usable and engaging. The study was limited to evaluate usability only and not the clinical effectiveness of the app.
Recurrent Primary Intrasellar Paraganglioma
(Hindawi, 2020-06-26) Schueth, Elizabeth A.; Martinez, Daniel C.; Kulwin, Charles G.; Bonnin, Jose M.; Payner, Troy D.; Ting, Jonathan Y.; Otolaryngology – Head and Neck Surgery, School of Medicine
We describe a case of an 81-year-old male presenting with bitemporal visual field defects and blurry vision in the right eye. The patient was found to have a recurrent primary paraganglioma in the sellar and suprasellar region requiring a repeat transsphenoidal endoscopic resection. Immunohistochemical examination confirmed paraganglioma with the classic zellballen appearance which stained positive for chromogranin, synaptophysin, and S-100 in the periphery. Paragangliomas (PGLs) in the sella turcica are a rare entity; only 19 cases have ever been reported in the literature. PGLs in the sellar region are often misdiagnosed or diagnosed in a delayed fashion. Earlier diagnosis of this locally aggressive tumor and meticulous debulking can prevent morbidity secondary to the tumor's compressive effects. This report highlights the effectiveness of surgical interventions in treatment of paragangliomas. More research is still needed to determine the need for adjuvant therapies such as radiation.

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