Serum high mobility group box 1 protein levels are not associated with either histological severity or treatment response in children and adults with nonalcoholic fatty liver disease

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dc.contributor.authorYates, Katherine P.
dc.contributor.authorDeppe, Ross
dc.contributor.authorComerford, Megan
dc.contributor.authorMasuoka, Howard
dc.contributor.authorCummings, Oscar W.
dc.contributor.authorTonascia, James
dc.contributor.authorChalasani, Naga
dc.contributor.authorVuppalanchi, Raj
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2018-05-16T12:50:15Z
dc.date.available2018-05-16T12:50:15Z
dc.date.issued2017-11-02
dc.description.abstractAim Serum high mobility group box 1 protein (HMGB1) is a proinflammatory molecule that could potentially serve as a biomarker for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) due to its correlation with degree of liver fibrosis. The aim of the current study was to examine the cross-sectional and longitudinal relationships between serum HMGB1 levels and liver histology in adults and children with NAFLD participating in two large randomized controlled trials. Methods Serum HMGB1 levels were measured at various time points in adults and children with NAFLD, who participated in PIVENS and TONIC clinical trials respectively. PIVENS trial compared vitamin E or pioglitazone to placebo in adults whereas TONIC trial compared vitamin E or metformin to placebo in children. Participants had liver biopsies at baseline and the end of treatment (96 weeks), and liver histology was reviewed by a central committee of study pathologists. Results In the cross-sectional analyses (n = 205 for PIVENS and 109 for TONIC), there was no significant relationship between serum HMGB1 levels and histological features such as steatosis, ballooning, inflammation, fibrosis, or presence of steatohepatitis in either adults or children. Serum HMGB1 levels did not change significantly during treatment either with placebo, vitamin E therapy (P = 0.81) or pioglitazone (P = 0.09) in the PIVENS trial. Similarly, serum HMGB1 levels did not change significantly during treatment either with placebo, metformin (P = 0.15) or vitamin E (P = 0.23) in the TONIC trial. In the longitudinal analyses (n = 105 for PIVENS and 109 for TONIC), changes in serum HMGB1 levels did not correlate with histologic improvement or resolution of NASH in either adults or children. There was no relationship between serum HMGB1 and ALT levels in either adults or children with NAFLD. Conclusion Serum HMGB1 levels were not associated with histological severity or treatment response in either children or adults with NAFLD.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationYates, K. P., Deppe, R., Comerford, M., Masuoka, H., Cummings, O. W., Tonascia, J., … Vuppalanchi, R. (2017). Serum high mobility group box 1 protein levels are not associated with either histological severity or treatment response in children and adults with nonalcoholic fatty liver disease. PLoS ONE, 12(11). https://doi.org/10.1371/journal.pone.0185813en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttps://hdl.handle.net/1805/16192
dc.language.isoen_USen_US
dc.publisherPLOSen_US
dc.relation.isversionof10.1371/journal.pone.0185813en_US
dc.relation.journalPLoS ONEen_US
dc.rightsAttribution 3.0 United States
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/
dc.sourcePMCen_US
dc.subjectCross-Sectional Studiesen_US
dc.subjectHigh Mobility Group Proteinsen_US
dc.subjectNon-alcoholic Fatty Liver Diseaseen_US
dc.subjectprotein blood levelen_US
dc.subjectliver fibrosisen_US
dc.subjectliver biopsyen_US
dc.subjectalpha tocopherolen_US
dc.titleSerum high mobility group box 1 protein levels are not associated with either histological severity or treatment response in children and adults with nonalcoholic fatty liver diseaseen_US
dc.typeArticleen_US
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