Bone marrow fat is increased in chronic kidney disease by magnetic resonance spectroscopy

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dc.contributor.authorMoorthi, R. N.
dc.contributor.authorFadel, W.
dc.contributor.authorEckert, G. J.
dc.contributor.authorPonsler-Sipes, K.
dc.contributor.authorMoe, S. M.
dc.contributor.authorLin, C.
dc.contributor.departmentDepartment of Medicine, IU School of Medicineen_US
dc.date.accessioned2017-01-03T18:07:46Z
dc.date.available2017-01-03T18:07:46Z
dc.date.issued2015-06
dc.description.abstractIn aging, the bone marrow fills with fat and this may lead to higher fracture risk. We show that a bone marrow fat measurement by magnetic resonance spectroscopy (MRS), a newer technique not previously studied in chronic kidney disease (CKD), is useful and reproducible. CKD patients have significantly higher bone marrow fat than healthy adults. INTRODUCTION: Renal osteodystrophy leads to increased morbidity and mortality in patients with CKD. Traditional bone biopsy histomorphometry is used to study abnormalities in CKD, but the bone marrow, the source of osteoblasts, has not been well characterized in patients with CKD. METHODS: To determine the repeatability of bone marrow fat fraction assessment by MRS and water-fat imaging (WFI) at four sites in patients with CKD, testing was performed to determine the coefficients of reproducibility and intraclass coefficients (ICCs). We further determined if this noninvasive technique could be used to determine if there are differences in the percent bone marrow fat in patients with CKD compared to matched controls using paired t tests. RESULTS: The mean age of subjects with CKD was 59.8 ± 7.2 years, and the mean eGFR was 24 ± 8 ml/min. MRS showed good reproducibility at all sites in subjects with CKD and controls, with a coefficient of reproducibilities ranging from 2.4 to 13 %. MRS and WFI assessment of bone marrow fat showed moderate to strong agreement (ICC 0.6-0.7) at the lumbar spine, with poorer agreement at the iliac crest and no agreement at the tibia. The mean percent bone marrow fat at L2-L4 was 13.8 % (95 % CI 8.3-19.7) higher in CKD versus controls (p < 0.05). CONCLUSIONS: MRS is a useful and reproducible technique to study bone marrow fat in CKD. Patients with CKD have significantly higher bone marrow fat than healthy adults; the relationship with bone changes requires further analyses.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationMoorthi, R. N., Fadel, W., Eckert, G. J., Ponsler-Sipes, K., Moe, S. M., & Lin, C. (2015). Bone marrow fat is increased in chronic kidney disease by magnetic resonance spectroscopy. Osteoporosis International : A Journal Established as Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 26(6), 1801–1807. http://doi.org/10.1007/s00198-015-3064-7en_US
dc.identifier.issn1433-2965en_US
dc.identifier.urihttps://hdl.handle.net/1805/11754
dc.language.isoen_USen_US
dc.publisherSpringer-Verlagen_US
dc.relation.isversionof10.1007/s00198-015-3064-7en_US
dc.relation.journalOsteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USAen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectAdipose Tissueen_US
dc.subjectpathologyen_US
dc.subjectBone Marrowen_US
dc.subjectRenal Insufficiency, Chronicen_US
dc.titleBone marrow fat is increased in chronic kidney disease by magnetic resonance spectroscopyen_US
dc.typeArticleen_US
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