Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease

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dc.contributor.authorJiang, Yanchao
dc.contributor.authorZhang, Ting
dc.contributor.authorKusumanchi, Praveen
dc.contributor.authorHan, Sen
dc.contributor.authorYang, Zhihong
dc.contributor.authorLiangpunsakul, Suthat
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2020-06-24T20:05:52Z
dc.date.available2020-06-24T20:05:52Z
dc.date.issued2020-03
dc.description.abstractOnce ingested, most of the alcohol is metabolized in the liver by alcohol dehydrogenase to acetaldehyde. Two additional pathways of acetaldehyde generation are by microsomal ethanol oxidizing system (cytochrome P450 2E1) and catalase. Acetaldehyde can form adducts which can interfere with cellular function, leading to alcohol-induced liver injury. The variants of alcohol metabolizing genes encode enzymes with varied kinetic properties and result in the different rate of alcohol elimination and acetaldehyde generation. Allelic variants of these genes with higher enzymatic activity are believed to be able to modify susceptibility to alcohol-induced liver injury; however, the human studies on the association of these variants and alcohol-associated liver disease are inconclusive. In addition to acetaldehyde, the shift in the redox state during alcohol elimination may also link to other pathways resulting in activation of downstream signaling leading to liver injury.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationJiang, Y., Zhang, T., Kusumanchi, P., Han, S., Yang, Z., & Liangpunsakul, S. (2020). Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease. Biomedicines, 8(3), 50. https://doi.org/10.3390/biomedicines8030050en_US
dc.identifier.urihttps://hdl.handle.net/1805/23082
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.isversionof10.3390/biomedicines8030050en_US
dc.relation.journalBiomedicinesen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourcePMCen_US
dc.subjectAlcohol metabolizing enzymeen_US
dc.subjectCytochrome P450 2E1en_US
dc.subjectAlcohol-associated liver diseaseen_US
dc.titleAlcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Diseaseen_US
dc.typeArticleen_US
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